ASTRO: Similar long-term AEs for short-term RT after prostatectomy – Consumer Health News


FRIDAY, October 29, 2021 (HealthDay News) – For patients undergoing prostatectomy for prostate cancer, postoperative hypofractionated prostate bed radiation therapy (HYPORT) is similar to conventional fractional postoperative radiation therapy (COPORT) in regards to the end of the genitourinary (GU) or gastrointestinal (GI) system, according to a study presented at the annual meeting of the American Society for Radiation Oncology, held October 24-27 in Chicago .

Mark K. Buyyounouski, MD, of Stanford University School of Medicine in California, and colleagues randomly assigned 296 prostate cancer patients to HYPORT (62.5 Gy in the prostate bed in 25 fractions of 2, 5 Gy; 144 patients) or COPORT (66.6 Gy in 37 fractions of 1.8 Gy; 152 patients). Co-primary endpoints were based on the GU and GI domain change scores of the composite Expanded Prostate Cancer Index score.

The researchers found that the differences between the mean GU HYPORT and COPORT change scores were neither clinically nor statistically significant at the end of RT and remained so at six and 12 months. At the end of RT, the differences in mean gastrointestinal change scores for HYPORT and COPORT were clinically significant and statistically significant, but these differences were resolved at six and 12 months. The differences in the 24-month mean GU and GI change scores for HYPORT and COPORT were neither clinically nor statistically significant.

“Providing postprostatectomy radiation therapy with fewer treatments is a victory when it comes to reducing the burden of prostate cancer on society,” Buyyounouski said in a statement.

Several authors have revealed financial links with the pharmaceutical and publishing industries.

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